External Collaborators

In collaboration with the lab of Martin Jakobsen, we have investigated the molecular mechanisms by which primary fibroblasts from mucosal tissues promote HIV infection of cellular targets. Ongoing work examines the effects of type I IFN on HIV replication and reservoir reactivation, and the intracellular sensing of HIV.

In collaboration with the lab of Eliver Ghosn, we have been interrogating systemic and mucosal antibody responses to SARS-CoV-2. Other collaborative work includes characterizing the properties of tissue-resident B cells in the female reproductive tract by deep-phenotyping and multi-omics single-cell analysis approaches.

We have a long-standing collaboration with the labs of Jan Münch and and Frank Kirchhoff. Together with the lab of Warner Greene at the J. David Gladstone Institutes, our labs have together extensively characterized the effects of semen and semen factors on HIV infection, HIV microbicides, and reproductive health. Ongoing collaborations seek to characterize the effects of various HIV accessory gene products on HIV replication in primary cells, and to characterize viral pathogenesis including in the context of COVID-19.

In collaboration with the lab of Mohamed Abdel-Mohsen, we have defined the glycan features of HIV-susceptible cells and the extent to which HIV modifies cell-surface host glycans. Current work uses CyTOF and other single-cell based glycan analysis tools to characterize features of HIV reservoir cells.

In collaboration with the lab of Nancie Archin, we have characterized the phenotypic features of HIV reservoir cells from tissues of ART-suppressed people living with HIV. Ongoing work characterizes the mechanisms of HIV persistence in tissues and ways to eradicate the tissue reservoir, particularly that of the gut.