Our research spans a range of topics, from understanding HIV transmission and pathogenesis to deciphering the functions of mucosal factors in reproductive health.

 

fallopian tubes

The molecular basis by which small amounts of HIV can initiate infection in the mucosa is not well understood. We have discovered that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells.

Seminal Plasma

Semen, in contrast to other human bodily fluids, contains multiple types of amyloid fibrils under non-diseased conditions. We have demonstrated that these fibrils potently enhance infection by HIV and other sexually transmitted viruses, and characterized the mechanisms by which they do so.

Tissue Cells to HIV

Mass cytometry, or CyTOF, is a powerful technology that has been used for comprehensive multiparameter characterization of immune cells. In collaboration with Dr. Marielle Cavrois (The J.