Our research spans a range of topics, from understanding HIV transmission and pathogenesis to deciphering the functions of mucosal factors in reproductive health. We conduct our studies using a combination of ex vivo models to direct analysis of patient samples. 


Tissue Cells to HIV

Mass cytometry, or CyTOF, is a powerful technology that has been used for comprehensive multiparameter characterization of immune cells.

fallopian tubes

The molecular basis by which small amounts of HIV can initiate infection in the mucosa is not well understood. We have discovered that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells.

SARS-CoV-2, a new SARS-related Betacoronavirus first reported in December 2019, quickly spread around the world causing an outbreak that was declared a pandemic in March 2020.

Seminal Plasma

Semen, in contrast to other human bodily fluids, contains multiple types of amyloid fibrils under non-diseased conditions. We have demonstrated that these fibrils potently enhance infection by HIV and other sexually transmitted viruses, and characterized the mechanisms by which they do so.