Our research spans a range of topics, from understanding HIV transmission and pathogenesis to deciphering the functions of mucosal factors in reproductive health. We conduct our studies using a combination of ex vivo models to direct analysis of patient samples. 


Tissue Cells to HIV

Mass cytometry, or CyTOF, is a powerful technology that has been used for comprehensive multiparameter characterization of immune cells.

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The molecular basis by which small amounts of HIV can initiate infection in the mucosa is not well understood. We have discovered that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells.

SARS-CoV-2, a new SARS-related Betacoronavirus first reported in December 2019, quickly spread around the world causing an outbreak that was declared a pandemic in March 2020. We have characterized global and antigen-specific immune responses to SARS-CoV-2 in the context of mild vs.

Reproductive Health

The endometrium of the upper female reproductive tract is a unique, hormone-responsive tissue that must tackle the dual challenges of preventing infection by pathogenic microbes while establishing a tolerogenic environment for pregnancy.